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Scientific Achievements

  • First successful development of a culture system for infectious HCV of genotype 1b (Coito et al, in preparation, 2007).
  • First laboratory to discover human obese adults with a complete deficiency of leptin (Nature Genetics 18,213-215, 1998). These monogenic obese patients were later treated with recombinant leptin successfully.
  • One of the two laboratories to first identify a natural variant of human beta3 - adrenergic receptor (New Engl. J. Med. 333, 343-347, 1995) and to correlate this single substitution with increased obesity (New Engl. J. Med. 333, 352-354, 1995).
  • First laboratory to immortalize human fat-producing adipocytes (J. Cell. Sci.110, 801-807, 1997).
  • First to achieve functional expression of G protein-coupled receptors in E. coli bacteria: beta3 -adrenergic (Proc. Natl. Acad. Sci. USA 85, 7551-7555, [1988]; EMBO J. 9, 1471-1476, [1990]), 5HT1A serotonin (J. Biol. Chem. 267, 8200-8206, 1992) and beta2-adrenergic receptor-Gsa fusion protein (Proc. Natl. Acad. Sci. USA 91, 8827-8831, 1994).
  • First to clone, sequence and express the human beta3-adrenergic receptor (Science 245, 1118-1121, 1989), to describe its pharmacology (Mol. Pharmacol. 44, 1094-1104, 1993), its expression in humans. (J. Clin. Invest. 91, 344-349, 1993).
  • One of two laboratories to first clone, sequence and express the human AT2 angiotensin II receptor (Eur. J. Biochem. 220, 919-926,1994) and to demonstrate coupling of its murine counterpart to a tyrosine phosphatase (Receptors & Channels 2, 271-280, 1994).
  • First to demonstrate that anti-idiotypic antibodies raised against anti-catecholamine antibodies, can recognize the beta adrenergic receptor (J. Exp. Med. 157, 1369-1378, 1983).
  • One of two laboratories to first clone, sequence and express the human beta2-adrenergic receptor (Proc. Natl. Acad. Sci. USA 84, 6995-6999, 1987).
  • First to isolate, to separate from adenylyl cyclase and to characterize a G protein-coupled receptor: the beta-adrenergic receptor from turkey erythrocytes (Proc. Natl. Acad. Sci. USA 74, 3710-3714, 1977).
  • First to reveal the existence and to characterize "latent allotypes" in rabbits (J. Immunol. 113, 1313-1318, 1974; Immunogenetics, 4, 499-513, 1977).
  • First to produce rabbit monoclonal antibodies in 1973, by immortalizing, using SV40 rabbit lymphocytes, producing anti-pneumoccal antibodies (Proc. Natl. Acad. Sci. USA 71, 263-264, 1974).
  • One of two laboratories to produce and sequence antibodies of restricted heterogeneity against microbial pneumoccus and micrococus antigens. (Biochemistry, 11, 4978-4985, 1972).